منابع مشابه
Graft-vs.-host Reaction in Tissue Culture
The primary purpose of this study has been to validate the in vitro graft-vs.-host reaction as an experimental system. Time-dose studies have been presented for cells obtained from spleen, thymus, cortisone-treated thymus, inguinal lymph node, mesenteric lymph node, thoracic duct, and bone marrow cells. Both the degree of splenomegaly and the onset of spleen enlargement were found to be depende...
متن کاملInhibition of Graft-vs .-host Reaction
When parental type lymphoid cells are injected into F1 hybrid animals there is usually a severe graft-vs .-host reaction (GVHR) . It has been shown that a proportion of animals will survive the acute episode, depending on the number of cells injected and the strain combination used, and that these animals are then tolerant to a second challenge by parental type cells (1) . We have previously sh...
متن کاملSerum-mediated inhibition of graft-vs.-host reaction
Rats recovering from a systemic graft-vs.-host reaction (GVHR) possess factors in the serum which can inhibit the production of a local GVHR. After incubation in vitro for 1 h at 37 degrees C these factors reduce the GVH-producing potential of parental spleen or lymph node cells to 24% of control cells treated with normal serum. These factors appear within 1 wk after initiation of a systemic GV...
متن کاملCytotoxicity in Graft-versus-host Reaction
Under in vitro conditions spleen cells from nonirradiated F(1) hybrids, in which a (graft-vs.-host) (GVH) reaction had been induced with lymphoid cells of parental origin, lysed nonspecifically target cells, i.e., cells syngeneic or allogeneic to the parental genotypes. Furthermore, tumor cells exposed in vitro to spleen cells of F(1) hybrid mice undergoing GVH reaction had markedly decreased a...
متن کاملGraft-versiiS-Host Reaction in Lymphoid Proliferation1
Graft-t'ersws-host reactions, which may occur following the inoculation of immunologically competent cells into susceptible antigenic hosts, initiate a complex immunopathologic syndrome. The most characteristic feature of this experimental disease is widespread involvement of lymphoid tissue, typified by an early proliferative phase followed by varying degrees of lymphoid de pletion and atrophy...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1973
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.138.6.1506